Two new studies further support the view that FENO predicts steroid response [1, 2], even in the absence of sputum eosinophilia [2]. Two other studies show the predictive value of exhaled NO for the development of respiratory symptoms and even clinical asthma in non-symptomatic individuals taken from normal populations [3, 4]. One study presents a correlation between exhaled NO and unstable asthma (risk of exacerbations etc) independent of conventional asthma severity classification [5]. Another study shows that exhaled NO at baseline predicts reduction in lung function over a 5-year period [6], supporting the results from van Veen et al published 2008 [7].
- Perez-de-Llano LA, Carballada F, Castro Anon O, Pizarro M, Golpe R, Baloira A, Vazquez Caruncho M, Boquete M. Exhaled nitric oxide predicts control in patients with difficult-to-treat asthma. Eur Respir J 2010; 35: 1221-1227.
- Cowan DC, Cowan JO, Palmay R, Williamson A, Taylor DR. Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax 2010; 65: 384-390.
- Olin AC, Rosengren A, Thelle DS, Lissner L, Toren K. Increased fraction of exhaled nitric oxide predicts new-onset wheeze in a general population. Am J Respir Crit Care Med 2010; 181: 324-327.
- Bastain TM, Islam T, Berhane KT, McConnell RS, Rappaport EB, Salam MT, Linn WS, Avol EL, Zhang Y, Gilliland FD. Exhaled nitric oxide, susceptibility and new-onset asthma in the children's health study. Eur Respir J 2010.
- Dweik RA, Sorkness RL, Wenzel S, Hammel J, Curran-Everett D, Comhair SA, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Israel E, Jarjour N, Moore W, Peters S, Teague G, Gaston B, Erzurum SC. Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med 2010; 181: 1033-1041.
- Contoli M, Baraldo S, Marku B, Casolari P, Marwick JA, Turato G, Romagnoli M, Caramori G, Saetta M, Fabbri LM, Papi A. Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up. J Allergy Clin Immunol 2010; 125: 830-837.
- van Veen IH, Ten Brinke A, Sterk PJ, Sont JK, Gauw SA, Rabe KF, Bel EH. Exhaled nitric oxide predicts lung function decline in difficult-to-treat asthma. Eur Respir J 2008; 32: 344-349.
Note:
Publications 1-6 are available as free abstracts. The full text has to be purchased from the publisher.
Publication 7 is free.