British Guideline on the Management of Asthma
Section 2.2.2 Test of Eosinophilic Airway Inflammation
"May have a role in assessing severity or response to treatment"
The first sentence states that “…eosinophilic airway inflammation can be detected in children non-invasively by induced sputum or FENO…” “…FENO can be performed from 3-4 years old…”
Section 2.5 Further Investigations That May be Useful in Patients with an Intermediate Probability of Asthma
“…raised sputum and FENO are more closely related to ICS response than other tests…”
Also, exhaled NO is included in this section in Table 7: Estimation of Sensitivity and Specificity where the “FENO normal range <25 ppb in untreated patients and has a high sensitivity and medium specificity”
Section 2.5.4 Tests of Eosinophilic Airway Inflammation
“..eosinophilic inflammation can be assed by sputum induction and FENO…”
Section 2.6.1 Monitoring in Primary Care, Table 8
“can be performed in children over 5 years old”, “immediate results available”, “reasonably close relationship between eosinophilic inflammation”.
Includes clinical algorithm for the interpretation of exhaled nitric oxide values.