Finnish Asthma Guidelines – “Diagnosis and Treatment of Asthma” – 19 May 2006 by the Käypä hoito (The Finnish Medical Society Duodecim), Article identificator: nak05372 (005.372) © 2006 Kustannus Oy Duodecim

Exhaled Nitric Oxide references in the Guideline are:

1. Alving K, Weitzberg E, Lundberg J M. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993;6:1368-70
2. Kharitonov SA, Yates D, Robbins RA ym. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994;343:133-5
3. Persson MG, Zetterström O, Argenius V, Ihre E, Gustafsson LE. Single breath nitric oxide measurements in asthmatic patients and smokers. Lancet 1994;343:146-7
4. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 1995;151:1894-9
5. Massaro AF, Gaston B, Kita D ym. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med 1995; 152: 800-3
6. Horvath I, Donnelly LE, Kiss A ym. Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am J Respir Crit Care Med 1998;158:1042-6
7. Verleden GM, Dupont LJ, Verpeut AC, Demedts MG. The effect of cigarette smoking on exhaled nitric oxide in mild steroid-naive asthmatics. Chest 1999;116:59-64
8. Jones S L, Kittelson J, Cowan JO ym. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am J Respir Crit Care Med 2001;164:738-43
9. Ekroos H, Karjalainen J, Sarna S, Laitinen LA, Sovijärvi AR. Short-term variability of exhaled nitric oxide in young male patients with mild asthma and in healthy subjects. Respir Med 2002;96:895-900
10. Kharitonov SA, Gonio F, Kelly C, Meah S, Barnes PJ. Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur J Respir J 2003;21:433-8
11. Horvath I. The exhaled biomarker puzzle: bacteria play their card in the exhaled nitric oxide-exhaled breath condensate nitrite game. Thorax 2005;60:179-80
12. Pijnenburg MW, Hofhuis W, Hop WC, De Jongste JC. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax 2005;60:215-8
13. Smith AD, Cowan JO, Filsell S ym. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J respir Crit Care Med 2004;169:473-8
14. Malmberg LP, Turpeinen H, Rytilä P, Sarna S, Haahtela T. Determinants of increased exhaled nitric oxide in patients with suspected asthma. Allergy 2005;60:464-8
15. Olin AC, Alving K, Thoren K. Exhaled nitric oxide: relation to sensitization and respiratory symptoms. Clin Exp Allergy 2004;34:221-6
16. Rouhos A, Ekroos E, Karjalainen J, Sarna S, Sovijärvi ARA. Exhaled nitric oxide and exercise-induced bronchoconstriction in young male conscripts: association only in atopics. Allergy 2005 (painossa).
17. Rouhos A, Kainu A, Sarna S, Karjalainen J, Sovijärvi A. Similar exhaled nitric oxide concentration in atopic and nonatopic adults without respiratory symptoms; reference values for clinical use. ERS congress, Copenhagen, 2005; hyväksytty esitettäväksi (abstrakti).
18. Lehtimaki L, Kankaanranta H ym. Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation. Am J Respir Crit Care Med. 2001;163:1557-61
19. Fabbri L, Peters SP, Pavord I ym. Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004. Am J Respir Crit Care Med 2005;171:686-8
20. Kharitonov SA, Barnes PH. Exhaled markers of inflammation. Curr Opin Allergy Clin Immunol 2001;1:217-24
21. Kharitonov SA, Barnes PJ. Exhaled markers of pulmonary disease. Am J Respir Crit Care Med 2001;163:1693-722
22. Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. Eur Respir J 1997;10:1683-93

23. Exhaled Nitric Oxide references in the Guideline are:

    1. Alving K, Weitzberg E, Lundberg J M. Increased amount of nitric oxide in exhaled air of asthmatics. Eur R

1. espir J 1993;6:1368-70
2. Kharitonov SA, Yates D, Robbins RA ym. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994;343:133-5
3. Persson MG, Zetterström O, Argenius V, Ihre E, Gustafsson LE. Single breath nitric oxide measurements in asthmatic patients and smokers. Lancet 1994;343:146-7
4. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 1995;151:1894-9
5. Massaro AF, Gaston B, Kita D ym. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med 1995; 152: 800-3
6. Horvath I, Donnelly LE, Kiss A ym. Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am J Respir Crit Care Med 1998;158:1042-6
7. Verleden GM, Dupont LJ, Verpeut AC, Demedts MG. The effect of cigarette smoking on exhaled nitric oxide in mild steroid-naive asthmatics. Chest 1999;116:59-64
8. Jones S L, Kittelson J, Cowan JO ym. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am J Respir Crit Care Med 2001;164:738-43
9. Ekroos H, Karjalainen J, Sarna S, Laitinen LA, Sovijärvi AR. Short-term variability of exhaled nitric oxide in young male patients with mild asthma and in healthy subjects. Respir Med 2002;96:895-900
10. Kharitonov SA, Gonio F, Kelly C, Meah S, Barnes PJ. Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur J Respir J 2003;21:433-8
11. Horvath I. The exhaled biomarker puzzle: bacteria play their card in the exhaled nitric oxide-exhaled breath condensate nitrite game. Thorax 2005;60:179-80
12. Pijnenburg MW, Hofhuis W, Hop WC, De Jongste JC. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax 2005;60:215-8
13. Smith AD, Cowan JO, Filsell S ym. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J respir Crit Care Med 2004;169:473-8
14. Malmberg LP, Turpeinen H, Rytilä P, Sarna S, Haahtela T. Determinants of increased exhaled nitric oxide in patients with suspected asthma. Allergy 2005;60:464-8
15. Olin AC, Alving K, Thoren K. Exhaled nitric oxide: relation to sensitization and respiratory symptoms. Clin Exp Allergy 2004;34:221-6
16. Rouhos A, Ekroos E, Karjalainen J, Sarna S, Sovijärvi ARA. Exhaled nitric oxide and exercise-induced bronchoconstriction in young male conscripts: association only in atopics. Allergy 2005 (painossa).
17. Rouhos A, Kainu A, Sarna S, Karjalainen J, Sovijärvi A. Similar exhaled nitric oxide concentration in atopic and nonatopic adults without respiratory symptoms; reference values for clinical use. ERS congress, Copenhagen, 2005; hyväksytty esitettäväksi (abstrakti).
18. Lehtimaki L, Kankaanranta H ym. Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation. Am J Respir Crit Care Med. 2001;163:1557-61
19. Fabbri L, Peters SP, Pavord I ym. Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004. Am J Respir Crit Care Med 2005;171:686-8
20. Kharitonov SA, Barnes PH. Exhaled markers of inflammation. Curr Opin Allergy Clin Immunol 2001;1:217-24
21. Kharitonov SA, Barnes PJ. Exhaled markers of pulmonary disease. Am J Respir Crit Care Med 2001;163:1693-722
22. Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. Eur Respir J 1997;10:1683-93

Exhaled Nitric Oxide references in the Guideline are:

1. Alving K, Weitzberg E, Lundberg J M. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993;6:1368-70
2. Kharitonov SA, Yates D, Robbins RA ym. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994;343:133-5
3. Persson MG, Zetterström O, Argenius V, Ihre E, Gustafsson LE. Single breath nitric oxide measurements in asthmatic patients and smokers. Lancet 1994;343:146-7
4. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 1995;151:1894-9
5. Massaro AF, Gaston B, Kita D ym. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med 1995; 152: 800-3
6. Horvath I, Donnelly LE, Kiss A ym. Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am J Respir Crit Care Med 1998;158:1042-6
7. Verleden GM, Dupont LJ, Verpeut AC, Demedts MG. The effect of cigarette smoking on exhaled nitric oxide in mild steroid-naive asthmatics. Chest 1999;116:59-64
8. Jones S L, Kittelson J, Cowan JO ym. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am J Respir Crit Care Med 2001;164:738-43
9. Ekroos H, Karjalainen J, Sarna S, Laitinen LA, Sovijärvi AR. Short-term variability of exhaled nitric oxide in young male patients with mild asthma and in healthy subjects. Respir Med 2002;96:895-900
10. Kharitonov SA, Gonio F, Kelly C, Meah S, Barnes PJ. Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur J Respir J 2003;21:433-8
11. Horvath I. The exhaled biomarker puzzle: bacteria play their card in the exhaled nitric oxide-exhaled breath condensate nitrite game. Thorax 2005;60:179-80
12. Pijnenburg MW, Hofhuis W, Hop WC, De Jongste JC. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax 2005;60:215-8
13. Smith AD, Cowan JO, Filsell S ym. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J respir Crit Care Med 2004;169:473-8
14. Malmberg LP, Turpeinen H, Rytilä P, Sarna S, Haahtela T. Determinants of increased exhaled nitric oxide in patients with suspected asthma. Allergy 2005;60:464-8
15. Olin AC, Alving K, Thoren K. Exhaled nitric oxide: relation to sensitization and respiratory symptoms. Clin Exp Allergy 2004;34:221-6
16. Rouhos A, Ekroos E, Karjalainen J, Sarna S, Sovijärvi ARA. Exhaled nitric oxide and exercise-induced bronchoconstriction in young male conscripts: association only in atopics. Allergy 2005 (painossa).
17. Rouhos A, Kainu A, Sarna S, Karjalainen J, Sovijärvi A. Similar exhaled nitric oxide concentration in atopic and nonatopic adults without respiratory symptoms; reference values for clinical use. ERS congress, Copenhagen, 2005; hyväksytty esitettäväksi (abstrakti).
18. Lehtimaki L, Kankaanranta H ym. Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation. Am J Respir Crit Care Med. 2001;163:1557-61
19. Fabbri L, Peters SP, Pavord I ym. Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004. Am J Respir Crit Care Med 2005;171:686-8
20. Kharitonov SA, Barnes PH. Exhaled markers of inflammation. Curr Opin Allergy Clin Immunol 2001;1:217-24
21. Kharitonov SA, Barnes PJ. Exhaled markers of pulmonary disease. Am J Respir Crit Care Med 2001;163:1693-722
22. Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. Eur Respir J 1997;10:1683-93
23. Smith A D, Taylor D R. Is exhaled nitric oxide measurement a useful clinical test in asthma? Curr Opin Allergy Clin Immunol 2005;5:49-56