Agreement between 6 and 10 s exhalation time in children
Ito et al (Pediatr Pulmonol. 2010; Jul 20. [Epub ahead of print]) have shown that children aged 8 years and more (n = 21) succeeded in measuring FENO on both time modes, whereas for children aged younger than 8 years (n = 25) success rates of the 10- and 6-sec mode were 60.0% and 92.0%, respectively. In conclusion, good agreement between FENO-10 and FENO-6, and the 6-sec mode of NIOX-MINO® is more feasible than 10-sec mode for measuring FENO in younger children.
McGill et al (Pediatr Pulmonol. 2006;41:1053-7) have previously validated NIOX MINO against the NIOX® in a pediatric population. They showed that exhaled NO values were comparable between the two devices when 6 s exhalation mode was used.
Note: 6 s exhalation is not part of the cleared Intended Use for NIOX MINO in the US and Canada